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李效寬,黃瑞麗,閆曦月,朱津瑞,楊光忠.膽酸鈉原料中有機溶劑殘留的研究[J].中南民族大學學報自然科學版,2019,(2):176-178
膽酸鈉原料中有機溶劑殘留的研究
Research of residual solvents in crude sodium cholate
  
DOI:10.12130/znmdzk.20190204
中文關鍵詞: 氣相色譜法  FID檢測器  膽酸鈉
英文關鍵詞: gas chromatography  flame ionization detector  sodium cholate
基金項目:國家自然科學基金資助項目(31370379)
作者單位
李效寬,黃瑞麗,閆曦月,朱津瑞,楊光忠* 中南民族大學 民族藥學國家級實驗教學示范中心,武漢 430074 
摘要點擊次數: 193
全文下載次數: 189
中文摘要:
      為建立氣相色譜-氫火焰離子化檢測法(GC-FID)定量測定膽酸鈉原料中乙醇、乙醚溶劑殘留的新方法,將膽酸鈉用乙腈提取,采用HP-INNO Wax PEG氣相毛細管柱分離,以氮氣為載氣,流速為1.5 mL·min-1,使用氫火焰離子化檢測器進行檢測,進樣口溫度為200 ℃,檢測器溫度為250 ℃.結果表明:膽酸鈉原料中乙醇、乙醚的百分含量分別為0.7, 0.9, 0.6 mg·g-1 和30, 40, 30 μg·g-1,按《中國藥典》,均處于正常范圍內.此方法簡便易操作,重現性好,可適用于膽酸鈉原料藥中殘留溶劑的研究和檢測.
英文摘要:
      In order to establish a new method for the quantitative determination of residual solvents(ethanol and ether)in sodium cholate by gas chromatography equipped with flame ionization detector (GC-FID) , sodium cholate was extracted by acetonitrile and separated on HP-INNO Wax PEG column by using nitrogen as the carrier gas(1.5 mL·min-1), with the detector temperature at 250 ℃ and the injection port temperature at 200 ℃.The results indicated that the contents of ethanol and ether in several crude sodium cholate samples were 0.7, 0.9, 0.6 mg·g-1 and 30, 40, 30 μg·g-1 respectively, which was within the specified range according to “Chinese Pharmacopeia”. This method is simple, easy to operate, and reproducible. It can be applied to the study and detection of residual solvents in crude sodium cholate.
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